Mostafa Akbarzadeh Khiavi  , Azam Safary , Mohammad Hossein Somi*
Colorectal cancer (CRC) as a malignancy shows high mortality rate worldwide because of metastasis and drug resistance. Targeted multimodal nanosystems (NSs) can be developed and used against CRC with much better clinical outcomes.
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Mostafa Akbarzadeh Khiavi , Azam Safary , Jaleh Barar , Hamed Farzi-Khajeh, Abolfazl Barzegari, Rahimeh Mousavi, Mohammad Hossein Somi* , Yadollah Omidi*
The current study introduces an efficient ROS-responsive enzyme-based nanobiosystem and its biological impact in colon cancer therapy. Based on physicochemical properties, AuNPs-PEG-RNase A effectively induced apoptosis in SW-480 colon cancer cells and resulted in a significant reduction in cancer cell viability.
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Roya Dolatkhah , Saeed Dastgiri , Amir Taher Eftekhar Sadat, Faris Farassati, Marzieh Nezamdoust, Mohammad Hossein Somi*
It has been suggested that the pattern of specific mutation including KRAS/NRAS/BRAF, are associated with different prognostic values and responses to anti-EGFR therapies.
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Nurul Azmir Amir Hashim , Sharaniza Ab-Rahim, Wan Zurinah Wan Ngah, Sheila Nathan, Nurul Syakima Ab Mutalib, Ismail Sagap, A. Rahman A. Jamal, Musalmah Mazlan*
Global Serum from metabolomics on colorectal cancer (CRC) identified 11 differential metabolites which able to identify a new set of sample with 80% of accuracy. Pathway analysis shows purine, catecholamine and amino acid metabolism were altered in CRC patients.
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Hazwani Mohd Yusof , Sharaniza Ab-Rahim, Wan Zurinah Wan Ngah, Sheila Nathan, A Rahman A Jamal, Musalmah Mazlan*
This study highlights the differential metabolite profiling in CRC cell lines corresponding to different stages.
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Ainaz Mihanfar, Bahman Yousefi, Saber Ghazizadeh Darband, Shirin Sadighparvar, Mojtaba Kaviani, Maryam Majidinia*
Treatment of SW-480 cancer cell lines with a combination of 5-FU and melatonin results in the increment in the sensitivity of cancer cells to 5-FU through downregulation of XIAP and survivin, as well as modulation of oxidative stress.
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Samaneh Tokhanbigli , Helia Alavifard , Hamid Asadzadeh Aghdaei, Mohammad Reza Zali, Kaveh Baghaei*
Combining LY6E loaded DC therapy with pioglitazone improved the DC therapy effect for colorectal cancer treatment. LY6E pulsed DCs excites the CD8 positive immune responses against colorectal models. Pioglitazone inhibits IL-6 axis and formation of CRC cell lines proliferation through IL-6/STAT3 by influencing the immunosuppressive feature of the tumor microenvironment.
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Mostafa Akbarzadeh-Khiavi , Azam Safary , Yadollah Omidi*
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